Llwytho...

The Structure-Activity Relationship of an Ozonide Carboxylic Acid (OZ78) Against Fasciola hepatica

In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small structural changes to 1 resulted most commonly in loss of activity against Fasciola hepatica in vivo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Zhou, Lin, Wang, Xiaofang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882029/
https://ncbi.nlm.nih.gov/pubmed/20423101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100226t
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