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The Structure-Activity Relationship of an Ozonide Carboxylic Acid (OZ78) Against Fasciola hepatica

In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small structural changes to 1 resulted most commonly in loss of activity against Fasciola hepatica in vivo...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Zhou, Lin, Wang, Xiaofang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882029/
https://ncbi.nlm.nih.gov/pubmed/20423101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100226t
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