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Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating them relative to gene transcription. In so doing,...

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Pubblicato in:Nat Commun
Autori principali: Georgakopoulos-Soares, Ilias, Koh, Gene, Momen, Sophie E., Jiricny, Josef, Hemberg, Martin, Nik-Zainal, Serena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181645/
https://ncbi.nlm.nih.gov/pubmed/32332764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15901-w
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