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Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating them relative to gene transcription. In so doing,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Georgakopoulos-Soares, Ilias, Koh, Gene, Momen, Sophie E., Jiricny, Josef, Hemberg, Martin, Nik-Zainal, Serena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181645/
https://ncbi.nlm.nih.gov/pubmed/32332764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15901-w
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