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Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

The mechanisms that underpin how insertions or deletions (indels) become fixed in DNA have primarily been ascribed to replication-related and/or double-strand break (DSB)-related processes. Here, we introduce a method to evaluate indels, orientating them relative to gene transcription. In so doing,...

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Vydáno v:Nat Commun
Hlavní autoři: Georgakopoulos-Soares, Ilias, Koh, Gene, Momen, Sophie E., Jiricny, Josef, Hemberg, Martin, Nik-Zainal, Serena
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181645/
https://ncbi.nlm.nih.gov/pubmed/32332764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15901-w
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