Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

BACKGROUND: To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used. In spite of its several strengths, the pentaplex assay...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Takehara, Yuko, Nagasaka, Takeshi, Nyuya, Akihiro, Haruma, Tomoko, Haraga, Junko, Mori, Yoshiko, Nakamura, Keiichiro, Fujiwara, Toshiyoshi, Boland, C. Richard, Goel, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767035/
https://ncbi.nlm.nih.gov/pubmed/29329588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1376-4
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