Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters

Bacterial culture broth extracts have been the starting point for the development of numerous therapeutics. However, only a small fraction of bacterial biosynthetic diversity is accessible using this strategy. Here, we apply a discovery approach that bypasses the culturing step entirely by bioinform...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Vila-Farres, Xavier, Chu, John, Inoyama, Daigo, Ternei, Melinda A., Lemetre, Christophe, Cohen, Louis J., Cho, Wooyoung, Reddy, Boojala Vijay B., Zebroski, Henry A., Freundlich, Joel S., Perlin, David S., Brady, Sean F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163397/
https://ncbi.nlm.nih.gov/pubmed/28055186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11861
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