Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus

The flippase MurJ is responsible for transporting the cell wall intermediate lipid II from the cytoplasm to the outside of the cell. While essential for the survival of bacteria, it remains an underexploited target for antibacterial therapy. The humimycin antibiotics are lipid II flippase (MurJ) inh...

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Dettagli Bibliografici
Pubblicato in:ACS Infect Dis
Autori principali: Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Freundlich, Joel S., Brady, Sean F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163398/
https://ncbi.nlm.nih.gov/pubmed/28845973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00056
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