Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus

The flippase MurJ is responsible for transporting the cell wall intermediate lipid II from the cytoplasm to the outside of the cell. While essential for the survival of bacteria, it remains an underexploited target for antibacterial therapy. The humimycin antibiotics are lipid II flippase (MurJ) inh...

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Publicado en:ACS Infect Dis
Main Authors: Chu, John, Vila-Farres, Xavier, Inoyama, Daigo, Gallardo-Macias, Ricardo, Jaskowski, Mark, Satish, Shruthi, Freundlich, Joel S., Brady, Sean F.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163398/
https://ncbi.nlm.nih.gov/pubmed/28845973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.7b00056
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