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Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome

Bioinformatic analysis of sequenced bacterial genomes has uncovered an increasing number of natural product biosynthetic gene clusters (BGCs) to which no known bacterial metabolite can be ascribed. One emerging method we have investigated for studying these BGCs is the synthetic-Bioinformatic Natura...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Chu, John, Vila-Farres, Xavier, Brady, Sean F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791521/
https://ncbi.nlm.nih.gov/pubmed/31545899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b07317
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