An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

The antibiotic paenimucillin A was originally identified using a culture-independent synthetic-bioinformatic natural product (syn-BNP) discovery approach. Here we report on a bioinformatics-guided survey of paenimucillin A analogs that led to the discovery of paenimucillin C. Paenimucillin C inhibit...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Vila-Farres, Xavier, Chu, John, Ternei, Melinda A., Lemetre, Christophe, Park, Steven, Perlin, David S., Brady, Sean F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784245/
https://ncbi.nlm.nih.gov/pubmed/29404414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00528-17
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