The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme

We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Norvil, Allison B, AlAbdi, Lama, Liu, Bigang, Tu, Yu Han, Forstoffer, Nicole E, Michie, Amie R, Chen, Taiping, Gowher, Humaira
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/
https://ncbi.nlm.nih.gov/pubmed/32123902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items