The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme

We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...

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Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: Norvil, Allison B, AlAbdi, Lama, Liu, Bigang, Tu, Yu Han, Forstoffer, Nicole E, Michie, Amie R, Chen, Taiping, Gowher, Humaira
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/
https://ncbi.nlm.nih.gov/pubmed/32123902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139
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