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The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/ https://ncbi.nlm.nih.gov/pubmed/32123902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139 |
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