The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme

We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Norvil, Allison B, AlAbdi, Lama, Liu, Bigang, Tu, Yu Han, Forstoffer, Nicole E, Michie, Amie R, Chen, Taiping, Gowher, Humaira
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/
https://ncbi.nlm.nih.gov/pubmed/32123902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139
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