DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells

DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo DNA methylation. While biochemical studies show that DNMT3L is capable of interacting with both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Veland, Nicolas, Lu, Yue, Hardikar, Swanand, Gaddis, Sally, Zeng, Yang, Liu, Bigang, Estecio, Marcos R, Takata, Yoko, Lin, Kevin, Tomida, Mary W, Shen, Jianjun, Saha, Debapriya, Gowher, Humaira, Zhao, Hongbo, Chen, Taiping
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326784/
https://ncbi.nlm.nih.gov/pubmed/30321403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky947
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