DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells

DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo DNA methylation. While biochemical studies show that DNMT3L is capable of interacting with both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Veland, Nicolas, Lu, Yue, Hardikar, Swanand, Gaddis, Sally, Zeng, Yang, Liu, Bigang, Estecio, Marcos R, Takata, Yoko, Lin, Kevin, Tomida, Mary W, Shen, Jianjun, Saha, Debapriya, Gowher, Humaira, Zhao, Hongbo, Chen, Taiping
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326784/
https://ncbi.nlm.nih.gov/pubmed/30321403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky947
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