DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells

DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo DNA methylation. While biochemical studies show that DNMT3L is capable of interacting with both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Veland, Nicolas, Lu, Yue, Hardikar, Swanand, Gaddis, Sally, Zeng, Yang, Liu, Bigang, Estecio, Marcos R, Takata, Yoko, Lin, Kevin, Tomida, Mary W, Shen, Jianjun, Saha, Debapriya, Gowher, Humaira, Zhao, Hongbo, Chen, Taiping
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326784/
https://ncbi.nlm.nih.gov/pubmed/30321403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky947
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