Wird geladen...

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur frequently in acute myeloid leukemia and other hematological malignancies, with the majority (∼60%) of mutations affecting a single amino acid, Arg882 (R882), in the catalytic domain. Although the mutations impair DNMT3A c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kim, Soo Jin, Zhao, Hongbo, Hardikar, Swanand, Singh, Anup Kumar, Goodell, Margaret A., Chen, Taiping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952368/
https://ncbi.nlm.nih.gov/pubmed/24167195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-483487
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!