A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur frequently in acute myeloid leukemia and other hematological malignancies, with the majority (∼60%) of mutations affecting a single amino acid, Arg882 (R882), in the catalytic domain. Although the mutations impair DNMT3A c...

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Bibliographic Details
Main Authors: Kim, Soo Jin, Zhao, Hongbo, Hardikar, Swanand, Singh, Anup Kumar, Goodell, Margaret A., Chen, Taiping
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952368/
https://ncbi.nlm.nih.gov/pubmed/24167195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-483487
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