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A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur frequently in acute myeloid leukemia and other hematological malignancies, with the majority (∼60%) of mutations affecting a single amino acid, Arg882 (R882), in the catalytic domain. Although the mutations impair DNMT3A c...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society of Hematology
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3952368/ https://ncbi.nlm.nih.gov/pubmed/24167195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-483487 |
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