Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML

The clinicopathologic features of DNA methyltransferase 3A (DNMT3A)-mutated de novo acute myeloid leukemia (AML), and the significance of variant type, variant allele frequency (VAF), and multiple concomitant DNMT3A mutations, remain poorly defined. We examined 104 DNMT3A-mutated de novo AML patient...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Narayanan, Damodaran, Pozdnyakova, Olga, Hasserjian, Robert P., Patel, Sanjay S., Weinberg, Olga K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238486/
https://ncbi.nlm.nih.gov/pubmed/34100902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2021004250
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