Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia

TP53 mutations are associated with poor outcomes in acute myeloid leukemia (AML). The prognostic impact of mutant TP53 (TP53(mut)) variant allelic frequency (VAF) is not well established, nor is how this information might guide optimal frontline therapy. We retrospectively analyzed 202 patients with...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Short, Nicholas J., Montalban-Bravo, Guillermo, Hwang, Hyunsoo, Ning, Jing, Franquiz, Miguel J., Kanagal-Shamanna, Rashmi, Patel, Keyur P., DiNardo, Courtney D., Ravandi, Farhad, Garcia-Manero, Guillermo, Takahashi, Koichi, Konopleva, Marina, Daver, Naval, Issa, Ghayas C., Andreeff, Michael, Kantarjian, Hagop, Kadia, Tapan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686900/
https://ncbi.nlm.nih.gov/pubmed/33211826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003120
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