Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia

TP53 mutations are associated with poor outcomes in acute myeloid leukemia (AML). The prognostic impact of mutant TP53 (TP53(mut)) variant allelic frequency (VAF) is not well established, nor is how this information might guide optimal frontline therapy. We retrospectively analyzed 202 patients with...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Short, Nicholas J., Montalban-Bravo, Guillermo, Hwang, Hyunsoo, Ning, Jing, Franquiz, Miguel J., Kanagal-Shamanna, Rashmi, Patel, Keyur P., DiNardo, Courtney D., Ravandi, Farhad, Garcia-Manero, Guillermo, Takahashi, Koichi, Konopleva, Marina, Daver, Naval, Issa, Ghayas C., Andreeff, Michael, Kantarjian, Hagop, Kadia, Tapan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686900/
https://ncbi.nlm.nih.gov/pubmed/33211826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003120
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