Prognostic and therapeutic impacts of mutant TP53 variant allelic frequency in newly diagnosed acute myeloid leukemia

TP53 mutations are associated with poor outcomes in acute myeloid leukemia (AML). The prognostic impact of mutant TP53 (TP53(mut)) variant allelic frequency (VAF) is not well established, nor is how this information might guide optimal frontline therapy. We retrospectively analyzed 202 patients with...

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Detaylı Bibliyografya
Yayımlandı:Blood Adv
Asıl Yazarlar: Short, Nicholas J., Montalban-Bravo, Guillermo, Hwang, Hyunsoo, Ning, Jing, Franquiz, Miguel J., Kanagal-Shamanna, Rashmi, Patel, Keyur P., DiNardo, Courtney D., Ravandi, Farhad, Garcia-Manero, Guillermo, Takahashi, Koichi, Konopleva, Marina, Daver, Naval, Issa, Ghayas C., Andreeff, Michael, Kantarjian, Hagop, Kadia, Tapan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2020
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686900/
https://ncbi.nlm.nih.gov/pubmed/33211826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003120
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