High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 World Health Organization classification and is associated with a favorable prognosis. Although previous studies have evaluated NPM1 in a binary fashion, little is known about the significance of...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Patel, Sanjay S., Kuo, Frank C., Gibson, Christopher J., Steensma, David P., Soiffer, Robert J., Alyea, Edwin P., Chen, Yi-Bin A., Fathi, Amir T., Graubert, Timothy A., Brunner, Andrew M., Wadleigh, Martha, Stone, Richard M., DeAngelo, Daniel J., Nardi, Valentina, Hasserjian, Robert P., Weinberg, Olga K.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265642/
https://ncbi.nlm.nih.gov/pubmed/29724895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-01-828467
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