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The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/ https://ncbi.nlm.nih.gov/pubmed/32123902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139 |
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