The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme

We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882His, in DNMT3A disrupts its cooperative mechanism and leads to reduced enzymatic activity, thus explaining the genomic hypomethylation in AML cells. However, the underlying cause of the oncogenic effect o...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Norvil, Allison B, AlAbdi, Lama, Liu, Bigang, Tu, Yu Han, Forstoffer, Nicole E, Michie, Amie R, Chen, Taiping, Gowher, Humaira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144950/
https://ncbi.nlm.nih.gov/pubmed/32123902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa139
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