Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns

Somatic DNMT3A mutations at R882 are frequently observed in AML patients including the very abundant R882H, but also R882C, R882P and R882S. Using deep enzymology, we show here that DNMT3A-R882H has more than 70-fold altered flanking sequence preferences when compared with wildtype DNMT3A. The R882H...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Emperle, Max, Adam, Sabrina, Kunert, Stefan, Dukatz, Michael, Baude, Annika, Plass, Christoph, Rathert, Philipp, Bashtrykov, Pavel, Jeltsch, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868496/
https://ncbi.nlm.nih.gov/pubmed/31620784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz911
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