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The DNMT3A R882H mutant displays altered flanking sequence preferences
The DNMT3A R882H mutation is frequently observed in acute myeloid leukemia (AML). It is located in the subunit and DNA binding interface of DNMT3A and has been reported to cause a reduction in activity and dominant negative effects. We investigated the mechanistic consequences of the R882H mutation...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5887309/ https://ncbi.nlm.nih.gov/pubmed/29518238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky168 |
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