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Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase

The Dnmt3a DNA methyltransferase has been shown to bind cooperatively to DNA and to form large multimeric protein/DNA fibers. However, it has also been reported to methylate DNA in a processive manner, a property that is incompatible with protein/DNA fiber formation. We show here that the DNA methyl...

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Main Authors: Emperle, Max, Rajavelu, Arumugam, Reinhardt, Richard, Jurkowska, Renata Z., Jeltsch, Albert
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207976/
https://ncbi.nlm.nih.gov/pubmed/25147181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.572032
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