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Function and disruption of DNA Methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation
The catalytic domain of Dnmt3a cooperatively multimerizes on DNA forming nucleoprotein filaments. Based on modeling, we identified the interface of Dnmt3a complexes binding next to each other on the DNA and disrupted it by charge reversal of critical residues. This prevented cooperative DNA binding...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258144/ https://ncbi.nlm.nih.gov/pubmed/21926161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr753 |
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