Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific transcriptional programs. Targeted epigenome editing is an emerging technology to specifically regulate cellular gene expression in order to modulate cell phenotypes or dissect the epigenetic mechanisms inv...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Stepper, Peter, Kungulovski, Goran, Jurkowska, Renata Z., Chandra, Tamir, Krueger, Felix, Reinhardt, Richard, Reik, Wolf, Jeltsch, Albert, Jurkowski, Tomasz P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Gene regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389507/
https://ncbi.nlm.nih.gov/pubmed/27899645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1112
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