Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L

The C-terminal domains of Dnmt3a and Dnmt3L form elongated heterotetramers (3L-3a-3a-3L). Analytical ultracentrifugation confirmed the Dnmt3a-C/3L-C complex exists as a 2:2 heterotetramer in solution. The 3a–3a interface is the DNA-binding site, while both interfaces are essential for AdoMet binding...

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Autores principales: Jurkowska, Renata Z., Anspach, Nils, Urbanke, Claus, Jia, Da, Reinhardt, Richard, Nellen, Wolfgang, Cheng, Xiaodong, Jeltsch, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2008
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2588524/
https://ncbi.nlm.nih.gov/pubmed/18945701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn747
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