Function and disruption of DNA Methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation

The catalytic domain of Dnmt3a cooperatively multimerizes on DNA forming nucleoprotein filaments. Based on modeling, we identified the interface of Dnmt3a complexes binding next to each other on the DNA and disrupted it by charge reversal of critical residues. This prevented cooperative DNA binding...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Rajavelu, Arumugam, Jurkowska, Renata Z., Fritz, Jürgen, Jeltsch, Albert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2012
Konular:
Gene Regulation, Chromatin and Epigenetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258144/
https://ncbi.nlm.nih.gov/pubmed/21926161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr753
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller