Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2

Despite their central importance in mammalian development, the mechanisms that regulate the DNA methylation machinery and thereby the generation of genomic methylation patterns are still poorly understood. Here, we identify the 5mC-binding protein MeCP2 as a direct and strong interactor of DNA methy...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rajavelu, Arumugam, Lungu, Cristiana, Emperle, Max, Dukatz, Michael, Bröhm, Alexander, Broche, Julian, Hanelt, Ines, Parsa, Edris, Schiffers, Sarah, Karnik, Rahul, Meissner, Alexander, Carell, Thomas, Rathert, Philipp, Jurkowska, Renata Z, Jeltsch, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158614/
https://ncbi.nlm.nih.gov/pubmed/30102379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky715
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