Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2

Despite their central importance in mammalian development, the mechanisms that regulate the DNA methylation machinery and thereby the generation of genomic methylation patterns are still poorly understood. Here, we identify the 5mC-binding protein MeCP2 as a direct and strong interactor of DNA methy...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Rajavelu, Arumugam, Lungu, Cristiana, Emperle, Max, Dukatz, Michael, Bröhm, Alexander, Broche, Julian, Hanelt, Ines, Parsa, Edris, Schiffers, Sarah, Karnik, Rahul, Meissner, Alexander, Carell, Thomas, Rathert, Philipp, Jurkowska, Renata Z, Jeltsch, Albert
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158614/
https://ncbi.nlm.nih.gov/pubmed/30102379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky715
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