The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids

Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genetic inhibition of TAZ reduced stemness and increased differ...

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Published in:Cell Stem Cell
Main Authors: Seneviratne, Ayesh K., Xu, Mingjing, Aristizabal Henao, Juan J., Fajardo, Val A., Hao, Zhenyue, Voisin, Veronique, Xu, G. Wei, Hurren, Rose, Kim, S., MacLean, Neil, Wang, Xiaoming, Gronda, Marcela, Jeyaraju, Danny, Jitkova, Yulia, Ketela, Troy, Mullokandov, Michael, Sharon, David, Thomas, Geethu, Chouinard-Watkins, Raphaël, Hawley, James R., Schafer, Caitlin, Yau, Helen Loo, Khuchua, Zaza, Aman, Ahmed, Al-awar, Rima, Gross, Atan, Claypool, Steven M., Bazinet, Richard P., Lupien, Mathieu, Chan, Steven, De Carvalho, Daniel D., Minden, Mark D., Bader, Gary D., Stark, Ken D., LeBlanc, Paul, Schimmer, Aaron D.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137093/
https://ncbi.nlm.nih.gov/pubmed/30930145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.02.020
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