Oncogenic ERG represses PI3K signaling through down-regulation of IRS2

Genomic rearrangements leading to the aberrant expression of ERG are the most common early events in prostate cancer and are significantly enriched for the concomitant loss of PTEN. Genetically engineered mouse models reveal that ERG overexpression alone is not sufficient to induce tumorigenesis, bu...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Mao, Ninghui, Gao, Dong, Hu, Wenhuo, Gadal, Sunyana, Hieronymus, Haley, Wang, Shangqian, Lee, Young Sun, Sullivan, Patrick, Zhang, Zeda, Choi, Danielle, Rosen, Neal, Sawyers, Charles L, Gopalan, Anuradha, Chen, Yu, Carver, Brett S
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127960/
https://ncbi.nlm.nih.gov/pubmed/32015092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1394
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