Oncogenic ERG represses PI3K signaling through down-regulation of IRS2

Genomic rearrangements leading to the aberrant expression of ERG are the most common early events in prostate cancer and are significantly enriched for the concomitant loss of PTEN. Genetically engineered mouse models reveal that ERG overexpression alone is not sufficient to induce tumorigenesis, bu...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Mao, Ninghui, Gao, Dong, Hu, Wenhuo, Gadal, Sunyana, Hieronymus, Haley, Wang, Shangqian, Lee, Young Sun, Sullivan, Patrick, Zhang, Zeda, Choi, Danielle, Rosen, Neal, Sawyers, Charles L, Gopalan, Anuradha, Chen, Yu, Carver, Brett S
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127960/
https://ncbi.nlm.nih.gov/pubmed/32015092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1394
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