Potent and Prolonged innate immune activation by enzyme-sensitive imidazoquinoline TLR7/8 agonist prodrug vesicles

Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic circulation. Here, we report on the design and synt...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Wang, Bi, Herck, Simon Van, Chen, Yong, Bai, Xiangyang, Zhong, Zifu, Deswarte, Kim, Lambrecht, Bart N., Sanders, Niek N., Lienenklaus, Stefan, Scheeren, Hans W., David, Sunil A., Kiessling, Fabian, Lammers, Twan, De Geest, Bruno G., Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116109/
https://ncbi.nlm.nih.gov/pubmed/32524819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01928
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