Potent and Prolonged innate immune activation by enzyme-sensitive imidazoquinoline TLR7/8 agonist prodrug vesicles

Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic circulation. Here, we report on the design and synt...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Wang, Bi, Herck, Simon Van, Chen, Yong, Bai, Xiangyang, Zhong, Zifu, Deswarte, Kim, Lambrecht, Bart N., Sanders, Niek N., Lienenklaus, Stefan, Scheeren, Hans W., David, Sunil A., Kiessling, Fabian, Lammers, Twan, De Geest, Bruno G., Shi, Yang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116109/
https://ncbi.nlm.nih.gov/pubmed/32524819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01928
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller