pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Agonists of Toll-like receptors (TLRs) are potent activators of the innate immune system and hold promise as vaccine adjuvant and for anticancer immunotherapy. Unfortunately, in soluble form they readily enter systemic circulation and cause systemic inflammatory toxicity. Here we demonstrate that by...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nuhn, Lutz, Vanparijs, Nane, De Beuckelaer, Ans, Lybaert, Lien, Verstraete, Glenn, Deswarte, Kim, Lienenklaus, Stefan, Shukla, Nikunj M., Salyer, Alex C. D., Lambrecht, Bart N., Grooten, Johan, David, Sunil A., De Koker, Stefaan, De Geest, Bruno G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961133/
https://ncbi.nlm.nih.gov/pubmed/27382168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600816113
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