Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: De Koker, S., Van Hoecke, L., De Beuckelaer, A., Roose, K., Deswarte, K., Willart, M. A., Bogaert, P., Naessens, T., De Geest, B. G., Saelens, X., Lambrecht, B. N., Grooten, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519561/
https://ncbi.nlm.nih.gov/pubmed/28729715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06236-6
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