pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Agonists of Toll-like receptors (TLRs) are potent activators of the innate immune system and hold promise as vaccine adjuvant and for anticancer immunotherapy. Unfortunately, in soluble form they readily enter systemic circulation and cause systemic inflammatory toxicity. Here we demonstrate that by...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nuhn, Lutz, Vanparijs, Nane, De Beuckelaer, Ans, Lybaert, Lien, Verstraete, Glenn, Deswarte, Kim, Lienenklaus, Stefan, Shukla, Nikunj M., Salyer, Alex C. D., Lambrecht, Bart N., Grooten, Johan, David, Sunil A., De Koker, Stefaan, De Geest, Bruno G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961133/
https://ncbi.nlm.nih.gov/pubmed/27382168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600816113
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky