Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA (mRNA) vaccines are now being intensively explored as therapeutic cancer vaccines. mRNA vaccines clearly benefit from wrapping the mRNA into nano-sized carriers such as lipoplexes that protect the mR...

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Dades bibliogràfiques
Publicat a:Mol Ther
Autors principals: De Beuckelaer, Ans, Pollard, Charlotte, Van Lint, Sandra, Roose, Kenny, Van Hoecke, Lien, Naessens, Thomas, Udhayakumar, Vimal Kumar, Smet, Muriel, Sanders, Niek, Lienenklaus, Stefan, Saelens, Xavier, Weiss, Siegfried, Vanham, Guido, Grooten, Johan, De Koker, Stefaan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154477/
https://ncbi.nlm.nih.gov/pubmed/27506450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.161
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