Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA (mRNA) vaccines are now being intensively explored as therapeutic cancer vaccines. mRNA vaccines clearly benefit from wrapping the mRNA into nano-sized carriers such as lipoplexes that protect the mR...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: De Beuckelaer, Ans, Pollard, Charlotte, Van Lint, Sandra, Roose, Kenny, Van Hoecke, Lien, Naessens, Thomas, Udhayakumar, Vimal Kumar, Smet, Muriel, Sanders, Niek, Lienenklaus, Stefan, Saelens, Xavier, Weiss, Siegfried, Vanham, Guido, Grooten, Johan, De Koker, Stefaan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154477/
https://ncbi.nlm.nih.gov/pubmed/27506450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.161
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