Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Cancer immunotherapy can induce durable antitumor responses. However, many patients poorly respond to such therapies. Here we describe a generic antitumor therapy that is based on the intratumor delivery of mRNA that codes for the necroptosis executioner mixed lineage kinase domain-like (MLKL) prote...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Van Hoecke, Lien, Van Lint, Sandra, Roose, Kenny, Van Parys, Alexander, Vandenabeele, Peter, Grooten, Johan, Tavernier, Jan, De Koker, Stefaan, Saelens, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109072/
https://ncbi.nlm.nih.gov/pubmed/30143632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05979-8
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