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Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

Vaccinia viruses (VACV) are a novel class of immune-oncolytic therapeutics and their mechanism of action is based both on their capacity to replicate selectively in cancer cells and to elicit danger signals that can boost anti-tumor immunity. We recently reported that the intratumor expression of ML...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Van Hoecke, Lien, Riederer, Stephanie, Saelens, Xavier, Sutter, Gerd, Rojas, Juan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458643/
https://ncbi.nlm.nih.gov/pubmed/32923163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1802968
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