Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

Given their high potential to evoke cytolytic T cell responses, tumor antigen-encoding messenger RNA (mRNA) vaccines are now being intensively explored as therapeutic cancer vaccines. mRNA vaccines clearly benefit from wrapping the mRNA into nano-sized carriers such as lipoplexes that protect the mR...

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Vydáno v:Mol Ther
Hlavní autoři: De Beuckelaer, Ans, Pollard, Charlotte, Van Lint, Sandra, Roose, Kenny, Van Hoecke, Lien, Naessens, Thomas, Udhayakumar, Vimal Kumar, Smet, Muriel, Sanders, Niek, Lienenklaus, Stefan, Saelens, Xavier, Weiss, Siegfried, Vanham, Guido, Grooten, Johan, De Koker, Stefaan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154477/
https://ncbi.nlm.nih.gov/pubmed/27506450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.161
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