Potent and Prolonged innate immune activation by enzyme-sensitive imidazoquinoline TLR7/8 agonist prodrug vesicles

Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic circulation. Here, we report on the design and synt...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Chem Soc
Egile Nagusiak: Wang, Bi, Herck, Simon Van, Chen, Yong, Bai, Xiangyang, Zhong, Zifu, Deswarte, Kim, Lambrecht, Bart N., Sanders, Niek N., Lienenklaus, Stefan, Scheeren, Hans W., David, Sunil A., Kiessling, Fabian, Lammers, Twan, De Geest, Bruno G., Shi, Yang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116109/
https://ncbi.nlm.nih.gov/pubmed/32524819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01928
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