Potent and Prolonged innate immune activation by enzyme-sensitive imidazoquinoline TLR7/8 agonist prodrug vesicles

Synthetic immune-stimulatory drugs such as agonists of the Toll-like receptors (TLR) 7/8 are potent activators of antigen-presenting cells (APCs), however, they also induce severe side effects due to leakage from the site of injection into systemic circulation. Here, we report on the design and synt...

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Pubblicato in:J Am Chem Soc
Autori principali: Wang, Bi, Herck, Simon Van, Chen, Yong, Bai, Xiangyang, Zhong, Zifu, Deswarte, Kim, Lambrecht, Bart N., Sanders, Niek N., Lienenklaus, Stefan, Scheeren, Hans W., David, Sunil A., Kiessling, Fabian, Lammers, Twan, De Geest, Bruno G., Shi, Yang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116109/
https://ncbi.nlm.nih.gov/pubmed/32524819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c01928
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