Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Hu, Kewen, Li, Kun, Lv, Jing, Feng, Jie, Chen, Jing, Wu, Haigang, Cheng, Feixiong, Jiang, Wenhao, Wang, Jieqiong, Pei, Haixiang, Chiao, Paul J., Cai, Zhenyu, Chen, Yihua, Liu, Mingyao, Pang, Xiufeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108883/
https://ncbi.nlm.nih.gov/pubmed/31874110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124049
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