Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Clin Invest
Main Authors: Hu, Kewen, Li, Kun, Lv, Jing, Feng, Jie, Chen, Jing, Wu, Haigang, Cheng, Feixiong, Jiang, Wenhao, Wang, Jieqiong, Pei, Haixiang, Chiao, Paul J., Cai, Zhenyu, Chen, Yihua, Liu, Mingyao, Pang, Xiufeng
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108883/
https://ncbi.nlm.nih.gov/pubmed/31874110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124049
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla