Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma

Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Hu, Kewen, Li, Kun, Lv, Jing, Feng, Jie, Chen, Jing, Wu, Haigang, Cheng, Feixiong, Jiang, Wenhao, Wang, Jieqiong, Pei, Haixiang, Chiao, Paul J., Cai, Zhenyu, Chen, Yihua, Liu, Mingyao, Pang, Xiufeng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108883/
https://ncbi.nlm.nih.gov/pubmed/31874110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124049
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares