ロード中...
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
Oncogenic KRAS is a major driver in lung adenocarcinoma (LUAD) that has yet to be therapeutically conquered. Here we report that the SLC7A11/glutathione axis displays metabolic synthetic lethality with oncogenic KRAS. Through metabolomics approaches, we found that mutationally activated KRAS strikin...
保存先:
| 出版年: | J Clin Invest |
|---|---|
| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2020
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7108883/ https://ncbi.nlm.nih.gov/pubmed/31874110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124049 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|