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Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers

KRAS is the most commonly mutated oncogene in human cancer. Most KRAS-mutant cancers depend on sustained expression and signaling of KRAS, thus making it a high-priority therapeutic target. Unfortunately, development of direct small molecule inhibitors of KRAS function has been challenging. An alter...

詳細記述

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書誌詳細
出版年:Cold Spring Harb Perspect Med
主要な著者: Aguirre, Andrew J., Hahn, William C.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990478/
https://ncbi.nlm.nih.gov/pubmed/29101114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031518
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