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Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers
KRAS is the most commonly mutated oncogene in human cancer. Most KRAS-mutant cancers depend on sustained expression and signaling of KRAS, thus making it a high-priority therapeutic target. Unfortunately, development of direct small molecule inhibitors of KRAS function has been challenging. An alter...
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| Published in: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5990478/ https://ncbi.nlm.nih.gov/pubmed/29101114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031518 |
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