Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromat...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gorecki, Lukas, Gerlits, Oksana, Kong, Xiaotian, Cheng, Xiaolin, Blumenthal, Donald K., Taylor, Palmer, Ballatore, Carlo, Kovalevsky, Andrey, Radić, Zoran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105318/
https://ncbi.nlm.nih.gov/pubmed/32019865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012400
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