Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat OP poisoning involves an oxime reactivator (2-PAM,...

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Dades bibliogràfiques
Autors principals: Cochran, Rory, Kalisiak, Jarosław, Küçükkılınç, Tuba, Radić, Zoran, Garcia, Edzna, Zhang, Limin, Ho, Kwok-Yiu, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191013/
https://ncbi.nlm.nih.gov/pubmed/21730071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264739
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