Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Exposure to OPs can lead to serious cardiovascular complications, respiratory compromise, and death. Current therapy to combat OP poisoning involves an oxime reactivator (2-PAM,...

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Bibliografski detalji
Glavni autori: Cochran, Rory, Kalisiak, Jarosław, Küçükkılınç, Tuba, Radić, Zoran, Garcia, Edzna, Zhang, Limin, Ho, Kwok-Yiu, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Enzymology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191013/
https://ncbi.nlm.nih.gov/pubmed/21730071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.264739
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